Senior Scientist

Vacancy posted: Monday, 13 February 2017

Salary: Competitive
Location: Grangemouth

Closing date: 27 February 2017

Piramal Healthcare Grangemouth is a world leader in antibody drug conjugate (ADC) development and manufacture.  With two ADCs already on the market and many more in the pipeline, ADC’s are emerging as tomorrow’s safer, targeted and more effective cancer treatments.  We are a custom development manufacturing organisation and work with many of the biggest names in Pharma.  Our highly specialised site carries out projects from early stage drug development/proof of concept to tech transfer into our manufacturing facility.  As this industry continues to grow, we are expanding our research and development team to meet demand.  If a highly rewarding career in drug development appeals to you, then we would like to hear from you.

Key responsibilities of the Senior Scientist role include:

  • Conjugation of antibodies to cytotoxic drugs; purification of Antibody Drug Conjugate’s and an understanding of formulation
  • Leading a small development team to ensure projects are performed to the agreed scope and timelines
  • To plan and perform process robustness and optimisation studies
  • Product characterisation of the final Antibody Drug Conjugate to meet international regulatory requirements
  • Data interpretation, presenting/reporting conclusions and recommendations to both internal and external customers
  • Scaling up processes for internal production and/or technical transfer to our GMP facility
  • To provide technical support and advice between various departments, ensuring the successful transfer of processes
  • Supporting the introduction of processes into the manufacturing facility

Critical skills

  • Educated to higher degree level in a scientific discipline (chemistry / biochemistry) with at least 2 years relevant experience, or educated to degree level with at least 4 years relevant experience
  • A sound knowledge of protein analytical techniques such as UV/VIS, HPLC techniques
  • Excellent communication and presentation skills
  • Ability to lead and successfully manage a team
  • A proven track record of planning development work programmes
  • Management / execution of projects according to timelines and project budgets
  • Data interpretation and coherent conclusions / presentations
  • Independent and analytical thinking

Highly desirable:

  • Experience in process development within a regulated GLP or GMP environment
  • Understanding of regulatory guidelines
  • Background knowledge in organic chemistry, immunology and protein structure / function
  • Protein purification experience including Tangential Flow Filtration and (Akta) Chromatography
  • Previous experience in bioconjugation
  • Knowledge of design of experiments

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About Piramal Healthcare Ltd

Piramal Grangemouth is a key division of Piramal Healthcare which manufactures Antibody Drug Conjugates (ADCs), a highly promising new class of medicines for the treatment of cancer. Piramal Grangemouth is a world leader in the development and manufacture of ADCs having vast experience in commercial manufacture, process development and all phases of clinical trial manufacture.

Piramal Healthcare is a world leading global pharmaceutical company with revenue of over $700m/p.a and is recognised as a key player in contract manufacturing. We're the fourth largest pharmaceutical company in India with manufacturing operations in India, UK, Germany, Canada and the USA.

View all jobs with Piramal Healthcare Ltd

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