Senior Scientist - Functional Genomics

Cancer Research UK

Senior Scientist - Functional Genomics


Cancer Research UK, Garnethill, Glasgow City

  • Full time
  • Permanent
  • Onsite working

Posted 3 weeks ago, 28 Jun | Get your application in now before you miss out!

Closing date: Closing date not specified

job Ref: 0db7b5c718984fefaf532ca6a354d28e

Full Job Description

  • Design and execute pooled CRISPR screens to identify and validate potential therapeutic targets in cancer.

  • Generate Cas9-expressing cell lines, produce lentiviral libraries, optimize screening conditions, and prepare samples for NGS.

  • To implement experimental plans over agreed timelines and to ensure that the objectives of the projects are met.

  • Lead on scientific builds to advance our functional genomics capabilities

  • Stay up-to-date with technological advancements and apply them to improve experimental design and assay performance.

    Experience using CRISPR gene-editing and performing cell culture with excellent aseptic technique.

  • Demonstrated experience in molecular biology, and assay development/optimization, experience in NGS data analysis is a plus.

  • Ability to work independently, contribute to experimental design, and troubleshoot effectively.

  • Eagerness to learn new techniques quickly.

  • Strong interpersonal skills and ability to collaborate effectively in a team.

  • Practical experience in CRISPR screening for target identification/validation is highly desirable.

  • Experience with disease-relevant cellular models (organoids, primary immune cells) and/or CRISPR base editing, perturb-seq, in vivo screening, CRISPR activation or combinatorial screening is a plus.

    At Cancer Research UK, we exist to beat cancer.

  • Are you a passionate Scientist looking for the opportunity to work on exciting drug discovery projects at the world's leading cancer research charity? This could be the perfect opportunity to utilise your expertise in a cause-driven environment helping Cancer Research to beat cancer sooner.

    About the team

    The Functional Genomics Centre (FGC) was established in 2019 as a collaboration between AstraZeneca and Cancer Research Horizons to build a centre focused on developing and applying genetic screening in the field of oncology. This role offers the unique opportunity to be part of an exciting team, operating at the forefront of research and technology development, whilst it is being applied to clinically actionable programs.

    About Cancer Research Horizons

    At Cancer Research UK, our focus is on beating cancer. As the world's biggest medical research charity, we've helped bring eleven new cancer drugs to market. However, there is still an urgent need to bring more effective treatments to patients faster.

    We have recently developed a new approach to driving therapeutic innovation through the creation of Cancer Research Horizons. We have brought together Cancer Research UK's established drug discovery teams under one organisation and leadership team, combining our unique pipeline of world class biology, cutting edge technology platforms and clinical expertise to 1) bring new treatments to patients faster and 2) tackle the biggest challenges in discovering cancer drugs by seeking out more radical ideas and embracing risk in our bid to achieve success.

    Based at the Babraham Research Campus, Cambridge, the Biomedical Campus in Cambridge, Granta Park in Cambridge, the Beatson Institute in Glasgow, the Francis Crick Institute in London, and Newcastle University, Cancer Research Horizons employs ~200 staff from both industrial and academic backgrounds.

    This role offers a unique opportunity to join an exciting team working at the forefront of research and technology development in a diverse scientific environment. You will collaborate with academia and pharma, applying cutting-edge technologies to clinically actionable programs. The ideal candidate is a strong team player with excellent communication and organizational skills, who can leverage their experience to lead projects and effectively incorporate and apply new technologies to drive project success. You'll also be surrounded by people who are as dedicated to beating cancer as you are.